Bat B-Cell Receptor CDR3 Repertoire Annotations and Comparative Analysis

Data Sheet 2 provides chromosome-level annotations of immunoglobulin heavy (IGH), kappa (IGK), and lambda (IGL) loci in two bat species, Rhinolophus ferrumequinum and Antrozous pallidus. The dataset includes B-cell receptor CDR3 repertoire sequences generated via 5'RACE and high-throughput sequencing from spleen and intestinal tissues of Hipposideros armiger and Rhinolophus pearsonii/pusillus bats. Author QinLu Liu uploaded the 29.1 MB DOCX file to figshare under a CC-BY-4.0 license, with a last update timestamp of 2026-05-20.

Use Cases

• Comparative evolutionary analysis of immunoglobulin loci based on annotated V, D, J, and constant region genes.
• Analysis of BCR CDR3 repertoire diversity and V/J gene usage patterns based on high-throughput sequencing data from bat tissues.
• Identification of conserved and species-specific motifs in CDR3 regions based on comparisons with human and mouse repertoires.
• Development of specialized analysis tools for bat immunogenomics based on the provided annotated gene sequences.

Strengths

• Provides first chromosome-level annotations for IGK and IGL loci in Rhinolophus ferrumequinum and IGH/IGL loci in Antrozous pallidus.
• Includes comparative analysis of BCR CDR3 repertoires against human and mouse, highlighting specific differences like N/P nucleotide addition/deletion patterns.
• Dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is contained in a 29.1 MB DOCX file, which may require format conversion for computational analysis.

Provenance

Source

figshare, author QinLu Liu.

Collection Method

Chromosome-level annotation and BCR repertoire construction via 5'RACE and high-throughput sequencing.

Time Range

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Freshness

Last updated 2026-05-20 04:34:13; freshness should be verified.

Geography

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