Anti-PD-1 Blockade in Pancreatic Cancer: Mouse Model Data

A 2026 study by Lingmin Jiang investigates the synergistic effects of low-intensity electric stimulation (LIES) and anti-PD-1 blockade on pancreatic ductal adenocarcinoma (PDAC) in mouse models. The dataset likely contains results from orthotopic PDAC models, in vitro assays, and immune profiling via flow cytometry, immunofluorescence, and single-cell RNA sequencing. It is published under a CC-BY-4.0 license on figshare.

Use Cases

• Analyzing tumor immune microenvironment remodeling based on flow cytometry and multicolor immunofluorescence data.
• Investigating epithelial-mesenchymal transition (EMT) and cell migration under varying electric field strengths.
• Studying macrophage polarization and CD8+ T cell activation following combination therapy.
• Exploring the activation of the JAK2-STAT3 pathway and PD-L1 expression in PDAC cells.

Strengths

• Includes data from multiple experimental modalities: orthotopic mouse models, in vitro assays, flow cytometry, immunofluorescence, and single-cell RNA sequencing.
• Published under an open CC-BY-4.0 license, facilitating reuse.
• Focuses on a specific and novel combination therapy approach for pancreatic cancer.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a single PDF file (837.1 KB), which may contain processed results rather than raw, structured data tables.

Provenance

Source

figshare, author Lingmin Jiang.

Collection Method

Data generated from orthotopic PDAC mouse models treated with LIES and anti-PD-1 blockade, supplemented by in vitro assays and sequencing.

Freshness

Last updated 2026-05-19 05:40:18; freshness should be verified.