Data Sheet 2_Anxiety is associated with systemic pro-inflammatory profile and plasma lipid

34 young adults (17 healthy controls, 17 with clinician-confirmed anxiety) were studied, with data collected by Sofía Bernal-Vega and last updated in March 2026. Plasma cytokine levels were quantified by multiplex immunoassay and targeted lipid profiling was performed by mass spectrometry. The dataset includes group comparisons and associations with anxiety severity assessed via standardized clinical instruments.

Use Cases

• Identify pro-inflammatory cytokine signatures associated with clinical anxiety based on plasma IL-6, MCP-1, and TNF-α levels.
• Explore potential lipid alterations in anxiety disorders based on targeted lipidomics data for ceramides and glycerolipids.
• Build regression models to examine relationships between cytokine levels and anxiety symptom severity within a clinical group.
• Validate exploratory findings on specific lipid species like DG 18:2/22:4 and LPC 24:1 in independent cohorts.

Strengths

• Includes data from 34 participants with clinician-confirmed diagnoses and matched healthy controls.
• Provides quantified plasma cytokine data from multiplex immunoassays and targeted lipid profiling from mass spectrometry.
• Anxiety severity was assessed using standardized clinical instruments.
• Results are presented with specific statistical methods (Mann-Whitney U, Spearman correlations, robust regression).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study's small sample size of 34 participants is noted as a limitation requiring validation in larger studies.

Provenance

Source

Sofía Bernal-Vega via figshare.

Collection Method

Plasma samples analyzed via multiplex immunoassay and mass spectrometry; clinical assessments via standardized instruments.

Freshness

Last updated 2026-03-18 07:35:27; freshness should be verified.

Geography

Likely Mexico, based on participant description.