APOE3-Christchurch Variant Effects on iPSC-Derived Mesenchymal Stromal Cell Functions

Data Sheet 2_APOE3-Christchurch variant enhances neurovascular support functions of iPSC-derived mesenchymal stromal cells.zip is a dataset by Paula J. Rodriguez Martinez, last updated on 2026-06-01. It contains data from a study comparing isogenic iPSC-derived mesenchymal stromal cells (iMSCs) with the protective APOE3-Christchurch variant to standard APOE3 iMSCs. The data likely includes results from immunosuppression assays, endothelial barrier and angiogenesis co-cultures, neurite outgrowth tests, and metabolic profiling.

Use Cases

• Compare immunosuppressive effects on LPS-induced NFκB activation based on the described THP1 cell assays.
• Analyze endothelial barrier resistance and angiogenic capacity based on the described co-culture experiments with endothelial cells.
• Evaluate neurite outgrowth promotion based on the described conditioned medium experiments.
• Investigate metabolic resilience differences between APOE3Ch and APOE3 iMSCs based on the mentioned metabolic profiling.

Strengths

• Dataset is focused on a specific, rare protective genetic variant (APOE3-Christchurch) relevant to Alzheimer's Disease research.
• Data compares isogenic cell lines, which controls for genetic background differences.
• The study measures multiple functional outcomes: immunosuppression, endothelial support, neurite outgrowth, and metabolism.

Limitations

• Row count and specific column-level documentation are unknown, which may limit suitability assessment.
• The dataset is relatively small at 1.9 MB, suggesting it may contain summary or processed results rather than raw high-throughput data.

Provenance

Source

Paula J. Rodriguez Martinez via figshare

Collection Method

Experimental data from in vitro cell culture assays using isogenic iPSC-derived mesenchymal stromal cells.

Freshness

Last updated 2026-06-01 04:21:03; freshness should be verified.