Case Report: Atypical Hemolytic Uremic Syndrome with Thalassemia and CFH Gene Mutation

A single case report of pregnancy-associated atypical hemolytic uremic syndrome (aHUS) in a patient with thalassemia and a complement factor H (CFH) gene mutation. The report details the diagnostic and therapeutic approach, including plasmapheresis, hemodialysis, eculizumab, and luspatercept. The dataset is a 781.1 KB PDF authored by Jing Wu and last updated on 2026-04-27.

Use Cases

• Analyze the 'two-hit' disease mechanism based on the interaction between thalassemia and CFH mutation described in the report
• Study treatment efficacy for atypical hemolytic uremic syndrome based on the described use of eculizumab and luspatercept
• Investigate pregnancy as a trigger for complement overactivation based on the case details
• Review diagnostic pathways for thrombotic microangiopathy based on the reported clinical presentation

Strengths

• Provides a detailed clinical narrative for a rarely reported disease combination
• Includes specific therapeutic interventions and patient outcomes
• Released under a permissive CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Clinical case documentation

Time Range

Covers a single patient case; specific dates are not provided.

Freshness

Last updated 2026-04-27 13:33:44; freshness should be verified

Geography

Geographic origin of the case is not specified.