Electrochemotherapy Drug Transport Simulations Across Electric Field and Infusion Profiles

A 5.5 MB PDF presents in silico findings from meshless and Boolean network simulations comparing transport and reaction mechanisms in electrochemotherapy. The study examines combinations of electric field magnitude (E), bloodstream velocity (λinl), and two pharmacokinetic profiles (TPK and UPK). It was authored by Fabián Mauricio Vélez Salazar and published in 2025.

Use Cases

• Analyze the influence of electric field magnitude (E) and bloodstream velocity (λinl) on the uniformity of transmembrane transport mechanisms.
• Compare the spatio-temporal evolution of extracellular, free intracellular, and bound intracellular concentration ratios between one-short tri-exponential (TPK) and uniform (UPK) pharmacokinetic profiles.
• Investigate the interaction between reaction and transport mechanisms (RTMs) such as extravasation and protein dissociation under specific permutations of E and λinl.
• Model the effects of vessel vasoconstriction and tissue porosity changes on drug delivery mechanisms arising from different E values (0 kV/m, 46 kV/m, 70 kV/m).

Strengths

• Simulations test specific, quantified parameter combinations: three E values (0, 46, 70 kV/m), three λinl values, and two PK profiles.
• Findings are based on in-house computational tools previously developed, calibrated, and validated.
• Dataset is openly shared under a CC BY 4.0 license.

Limitations

• The core data and results are embedded within a 5.5 MB PDF document, requiring extraction for computational analysis.
• No raw tabular or time-series simulation output data (rows, columns) is directly provided in the description.
• The study's conclusions are based on in silico modeling, requiring domain expertise in pharmacokinetics and electroporation for application.

Provenance

Source

figshare

Collection Method

In-house meshless code and Boolean model simulations for computational analysis.

Time Range

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Geography

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