Case Report: Cadonilimab Rechallenge After Multiorgan Immune-Related Adverse Events

A single clinical case report details the management of sequential immune-related adverse events in a patient with metastatic gastric-type endocervical adenocarcinoma. The report, authored by Zhan Peng and shared under a CC-BY-4.0 license, describes a 70-year-old female patient who developed cystitis, adrenal insufficiency, and diabetic ketoacidosis following cadonilimab therapy. The document was last updated on May 20, 2026, and is available as an 11.1 KB DOCX file.

Use Cases

• Study the timeline and management of sequential, multiorgan immune-related adverse events based on the detailed case narrative.
• Analyze the feasibility and outcomes of immunotherapy rechallenge after severe adverse events based on the reported 17-month progression-free survival.
• Review a documented instance of cadonilimab-induced cystitis, adrenal insufficiency, and diabetic ketoacidosis for educational or diagnostic reference.

Strengths

• The case report provides a detailed, longitudinal narrative of a rare clinical scenario involving three distinct adverse events.
• Includes specific clinical metrics such as a 17-month progression-free survival and 24 cycles of administered therapy.
• Shared under a permissive CC-BY-4.0 license, allowing for reuse and distribution.

Limitations

• The dataset is a single case report (n=1), which limits statistical generalizability.
• Row count and column-level documentation are absent; the data is unstructured text within a DOCX file.
• The 11.1 KB size indicates a very limited scope, containing only the text of the report.

Provenance

Source

Zhan Peng

Collection Method

Clinical documentation of a single patient case.

Time Range

Case timeline spans from therapy initiation through a 17-month follow-up period.

Freshness

Last updated 2026-05-20 05:46:07.