Data Sheet 2_Case Report: Tumor regression and neurological recovery in paraplegia from PO

A single-case clinical report details a 58-year-old male with hepatocellular carcinoma and T11 vertebral metastasis causing paraplegia. The dataset includes temporal data on targeted immunotherapy, electroacupuncture rehabilitation, and serial cytokine measurements over a 28-month follow-up period. Author Xionghao Pang published the data on figshare under a CC-BY-4.0 license.

Use Cases

• Analyzing temporal cytokine profiles (IL-1β, TNF-α, IFN-γ) relative to treatment milestones
• Studying associations between POLD1 mutations and immunotherapy sensitivity in low TMB/MSI-L contexts
• Investigating potential links between electroacupuncture, immune activation, and neurological recovery in spinal metastases

Strengths

• Includes detailed longitudinal cytokine measurements with specific fold-change calculations (e.g., IFN-γ up 96.1-fold)
• Provides a complete 28-month clinical timeline with specific treatment dates and dosages (e.g., atezolizumab 1200 mg Q3W)
• Documents a rare clinical scenario combining POLD1 mutation, low TMB (7.76% bMSI-L), and paraplegia recovery

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is from a single case report; findings are hypothesis-generating and not generalizable

Provenance

Source

figshare

Collection Method

Clinical case report data collection

Time Range

Treatment and follow-up from July 2021, with rehabilitation starting May 2023, over 28 months

Freshness

Last updated 2026-06-01 05:36:04; freshness should be verified