Biomarker and MARCoNS Culture Data for 188 CIRS Patients

188 adult patients evaluated for Chronic Inflammatory Response Syndrome contributed paired laboratory measurements for α-MSH, MMP-9, and VIP, alongside nasal culture results for multiple antibiotic-resistant staphylococci. Margaret DiTulio authored this retrospective observational cohort study, which was last updated on April 17, 2026. The analysis found a selective association between clearance of the resistant bacteria and higher circulating levels of the neuroimmune peptide α-MSH.

Use Cases

• Modeling longitudinal trajectories of neuroimmune biomarkers like α-MSH, MMP-9, and VIP based on paired timepoint data.
• Investigating associations between persistent nasal colonization with antibiotic-resistant bacteria and systemic biomarker levels.
• Training classifiers to predict bacterial culture status from biomarker profiles in patients with multisystem chronic illness.

Strengths

• Includes paired longitudinal measurements for three biomarkers (α-MSH, MMP-9, VIP) across two timepoints for each patient.
• Focuses on a specific clinical cohort of 188 patients evaluated within a CIRS-informed framework.
• Analysis reveals a specific, quantitative interaction: α-MSH increased by an estimated 10 pg/mL in the full cohort.

Limitations

• Row count and specific column-level documentation are unknown, requiring manual inspection after download.
• Data is from a single clinical site, which may limit generalizability to other populations.
• The dataset is small at 144.4 KB, indicating limited scope.

Provenance

Source

figshare, authored by Margaret DiTulio.

Collection Method

Retrospective observational cohort study from a single clinical site.

Freshness

Last updated 2026-04-17 04:11:58; freshness should be verified.