Rectal Cancer Alternative Splicing and Immune Profiles for Vaccine Design

TCGA-READ data analyzed for alternative splicing events and immune subtypes. The dataset includes 4480 upregulated and 3328 downregulated alternative splicing events, with 217 potential antigen genes identified. Author Jiawen Weng published the data on figshare in April 2026.

Use Cases

• Identify potential mRNA vaccine antigens based on upregulated alternative splicing anomalies and frameshift mutations
• Stratify rectal cancer patients into immune subtypes (C1/C2) for predicting response to CTLA-4/PD-1 blockade
• Analyze correlations between candidate antigens (e.g., FAM135A) and immune cell infiltration profiles

Strengths

• Identifies 217 potential antigen genes from intersecting upregulated AS anomalies and frameshift mutations
• Stratifies TCGA-READ samples into C1 and C2 subtypes with distinct survival and immune profiles
• Highlights specific candidate antigens (FAM135A, GAR1, CDIPT) with analysis of immune correlation

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect bias inherent to the TCGA-READ cohort and bioinformatics methods used

Provenance

Source

figshare

Collection Method

Public data and bioinformatics analysis of TCGA-READ (The Cancer Genome Atlas Rectal Adenocarcinoma)

Time Range

null

Freshness

Last updated 2026-04-13 04:35:32

Geography

null