ART Effects on Alveolar Macrophages: Single-Nucleus Transcriptomic and Epigenetic Analysis

A 144.0 KB PDF research article published on figshare in 2026 by Vinicius M. Fava. The study uses a systems immunology approach to evaluate the impact of continuous antiretroviral therapy (ART) on alveolar macrophages in people with HIV and on pre-exposure prophylaxis. Results indicate ART induces a progressive, duration-dependent senescence-like pro-inflammatory state and impairs interferon signaling.

Use Cases

• Studying the link between ART duration and cellular senescence based on the described progressive epigenetic and transcriptomic changes.
• Analyzing gene regulatory networks in alveolar macrophages based on the described single-nucleus level coordinated transcription factor data.
• Modeling impaired immune response to viral challenges based on the described interferon signaling alterations and ex vivo SARS-CoV-2 challenge results.
• Investigating non-AIDS comorbidities in PWH based on the described dysregulated physiological state in alveolar macrophages.

Strengths

• Data is derived from a described systems immunology approach, including single-nucleus level analysis.
• Findings are explicitly linked to the duration of antiretroviral therapy.
• The dataset is openly available under a CC-BY-4.0 license.

Limitations

• The primary data file is a 144.0 KB PDF, suggesting it is a research article rather than a raw data repository.
• Row count and column-level documentation are unknown, limiting direct analysis suitability.
• The description provides results but not the underlying structured data tables.

Provenance

Source

figshare

Collection Method

A systems immunology approach evaluating alveolar macrophages, as described in the research article.

Freshness

Last updated 2026-04-22 05:49:10.