Mouse IgA Biosynthesis and Secretion Data from CRISPR/Cas9-Edited Cells

A 11.5 MB PDF document authored by Chaoqun Cui and last updated in April 2026. It presents experimental data on the cooperative control of Immunoglobulin A synthesis and secretion by MZB1 and the J chain, using CRISPR/Cas9-edited mouse plasmacytoma cells and in vivo models.

Use Cases

• Modeling IgA assembly pathways based on the described roles of MZB1 and the J chain.
• Analyzing the impact of gene knockouts (MZB1, J chain) on IgA dimer and polymer formation.
• Investigating correlations between IgA form/abundance and susceptibility to DSS-induced colitis.
• Studying how IgA variation reshapes gut microbiota composition, as mentioned in the description.

Strengths

• Data is derived from controlled CRISPR/Cas9-edited cell lines and a mouse model, as described.
• Document is licensed under CC-BY-4.0, permitting open reuse.
• Includes in vivo validation linking molecular mechanisms to disease susceptibility and microbiome changes.

Limitations

• The primary data format is a PDF (11.5 MB); underlying raw data files are not specified.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Chaoqun Cui, via figshare.

Collection Method

Experimental data from CRISPR/Cas9-edited J558 plasmacytoma cells and a mouse model, as described.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026-04 17 04:11:57.

Geography

Laboratory study; geographic scope not specified.