TRIM28-MAVS Ubiquitination Data from Antiviral Signaling Study

21.6 MB of experimental data from a study on the TRIM28-MAVS axis in antiviral immunity. The dataset includes results from overexpression, knockdown, and ubiquitination assays, authored by Ruihua Xin and shared under a CC BY 4.0 license. Specific row and column counts are not provided.

Use Cases

• Analyze TRIM28 knockdown effects on type I IFN responses and RNA virus replication data.
• Examine protein interaction and ubiquitination assay results for the TRIM28-MAVS association.
• Investigate data from MAVS lysine mutant constructs (e.g., Lys136, Lys461) to assess ubiquitination site functionality.
• Study confocal microscopy data on CRM1-dependent nuclear export of TRIM28 during viral infection.

Strengths

• Data is directly linked to a published molecular biology study with defined experimental methods.
• Shared under a permissive CC BY 4.0 license for reuse and redistribution.
• Includes results from multiple validation systems (in vitro, in vivo AAV-mediated knockdown).

Limitations

• The 21.6 MB size suggests a limited scale, likely containing processed results rather than raw high-throughput data.
• Dataset structure, column names, and row counts are unspecified, complicating immediate analytical use.
• Focus is on a specific molecular pathway (TRIM28-MAVS), limiting broader biological applications.

Provenance

Source

Ruihua Xin, via figshare.

Collection Method

Experimental data from molecular biology techniques including confocal microscopy, co-immunoprecipitation, and in-cell ubiquitination assays.

Freshness

Last updated on 2026-03-24.