Maternal and Cord Blood Cytokine Profiles in Term and Preterm Labor

Cytokine, chemokine, and growth factor measurements from 48 analytes in paired maternal peripheral and umbilical cord blood samples. The dataset contains profiles from 78 pregnancies, including term births and two preterm birth subtypes. It was created by Tiantian Yu and last updated in April 2026.

Use Cases

• Classify preterm birth subtypes (S-PTB vs. PROM-PTB) using fetal cord blood levels of IFN-γ, IL-2Rα, MIP-1α, and eotaxin.
• Compare immune landscapes between maternal peripheral blood and cord blood compartments using the 48 measured cytokine and chemokine features.
• Identify correlated cytokine networks within cord blood samples, indicative of fetal immune structure.
• Train models to predict labor type based on fetal growth factor levels such as M-CSF and SCF.
• Analyze principal components of global cytokine profiles to assess overlap between term and preterm birth groups.

Strengths

• Includes paired samples from two biological compartments (maternal blood and cord blood) for 78 pregnancies.
• Profiles 48 specific immune mediators, including cytokines, chemokines, and growth factors.
• Distinguishes between three clinical groups: term birth, spontaneous preterm birth, and preterm birth with premature rupture of membranes.

Limitations

• Small sample size of 78 pregnancies limits statistical power for detecting subtle immune differences.
• Lacks demographic or clinical metadata (e.g., maternal age, gestational age at sample) which could be confounding factors.
• The 781.0 KB file size suggests a limited scope, likely containing summary or analyzed data rather than raw assay readings.

Provenance

Source

figshare, authored by Tiantian Yu.

Collection Method

Multiplex profiling of cytokines, chemokines, and growth factors from collected blood samples.

Freshness

Last updated in April 2026.