Gene Expression and Serum Protein Data for Pulmonary Arterial Hypertension Irreversibility

Transcriptomic and serum protein data from a study investigating the molecular switch from reversible to irreversible pulmonary arterial hypertension (PAH). The dataset includes results from weighted gene co-expression network analysis (WGCNA) of three public datasets and enzyme-linked immunosorbent assay (ELISA) measurements from 80 patient and control serum samples. The data was published by Genfa Xiao on figshare under a CC-BY-4.0 license.

Use Cases

• Validate lysosomal hub gene expression patterns based on the identified genes Ctsd, Ctsk, Ctsb, Ctsa, Pld3, Tpsab1, Lgals3, and Smpdl3a.
• Correlate serum protein levels of CTSD, CTSB, and LGALS3 with disease reversibility status based on the clinical sample results.
• Investigate pathways related to lysosomal enzyme trafficking and sorting based on the downregulated genes Gnptab, M6pr, and Arf1 highlighted in the analysis.
• Replicate the WGCNA module identification for PAH irreversibility using the described methodological approach.

Strengths

• Includes validation using independent datasets and clinical samples from 40 patients with CHD-PAH, 20 with CHD, and 20 healthy controls.
• Analysis identified specific gene modules and eight lysosomal hub genes associated with disease irreversibility.
• Dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (35.2 KB), indicating limited scope, likely containing summary or processed results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Combined analysis of three transcriptomic datasets from the Gene Expression Omnibus and original ELISA measurements from patient serum samples.

Freshness

Last updated 2026-05-21 05:36:15; freshness should be verified.