Synthetic Selenopeptide Designs for XP and Skin Cancer Treatment

A 191.8 KB PDF authored by Arthur Alves Coelho, uploaded on figshare in April 2026. The document describes the in silico design and evaluation of five novel selenopeptide sequences named Selera, with Selera-2 identified as the best model. It details docking analyses with therapeutic targets B-RAF and TrxR1 and proposes a recombinant expression plasmid vector.

Use Cases

• Benchmarking peptide design methods based on described physico-chemical and structural property evaluations
• Studying protein-ligand docking interactions based on the described analyses with B-RAF and TrxR1 targets
• Designing recombinant expression systems based on the proposed p-Sec Reg 1 plasmid vector
• Investigating antioxidant and photoprotective peptide properties for skin condition treatment

Strengths

• The document provides a detailed methodological description of designing five novel selenopeptide sequences
• Specific docking results are reported for therapeutic targets B-RAF and TrxR1
• A concrete plasmid vector design (p-Sec Reg 1) is proposed for expression

Limitations

• The underlying data (e.g., sequences, docking scores) is embedded in a PDF; column-level documentation is absent
• Row count is unknown, which may limit suitability assessment for computational reuse
• The 191.8 KB file size suggests a limited scope, likely containing summary results rather than raw datasets

Provenance

Source

Arthur Alves Coelho via figshare

Collection Method

In silico design and bioinformatic evaluation described in the PDF

Freshness

Last updated 2026-04-09 04:07:41