Tau Degrader Compound Data from Patient-Derived Neuronal Models

QC-01-175 was identified as a lead compound for degrading pathological tau protein. The dataset documents a medicinal chemistry campaign using frontotemporal dementia patient-derived iPSC neurons to discover and optimize tau-targeting protein degraders. M. Catarina Silva authored this study, last updated in April 2026.

Use Cases

• Analyze structure-activity relationships for different chemical series targeting tau degradation.
• Identify molecular compositions most efficient at degrading tau in human ex vivo neurons.
• Compare the tau degradation activity of final lead molecules like QC-01-175 in mutant neuronal models.

Strengths

• Data is derived from human patient iPSC-derived neuronal models, providing a disease-relevant cellular context.
• The study presents three final lead molecules with confirmed tau degradation activity.
• Documentation is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 14.2 MB DOCX file, primarily containing textual descriptions rather than structured, machine-readable data tables.
• Specific quantitative data points, sample sizes, and column definitions for screening results are not explicitly provided in the input.

Provenance

Source

figshare, authored by M. Catarina Silva.

Collection Method

Data generated from screening FTD-patient induced pluripotent stem cell (iPSC)-derived neurons expressing tau variants.

Freshness

Last updated on 2026-04-07.