DNER Drives Glycolytic Reprogramming in Renal Cell Carcinoma

A research data sheet from a study investigating the role of the DNER gene in clear cell renal cell carcinoma (ccRCC). The document details bioinformatic analyses and experimental validation linking DNER to metabolic reprogramming and immune microenvironment remodeling via the JAK2/STAT3 pathway. The dataset was authored by Anrui Li and last updated on May 22, 2026.

Use Cases

• Study the relationship between DNER expression and metabolic pathway activity in ccRCC based on the described bioinformatic screening.
• Investigate the link between tumor cell glycolysis and macrophage polarization based on the described signaling cascade.
• Explore potential therapeutic targets in ccRCC based on the described association with PARP inhibitor sensitivity.

Strengths

• The description provides a detailed mechanistic explanation of DNER's role in ccRCC progression.
• The dataset is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.
• The file size is 1.2 MB, indicating a manageable download.

Limitations

• The dataset is a single DOCX file; the underlying data tables, column definitions, and row counts are not specified.
• The description is a research summary; the raw experimental and bioinformatic data are not directly accessible in this listing.
• Freshness should be verified as the last update date is in the future (2026-05-22).

Provenance

Source

figshare

Collection Method

Integrated bioinformatic analysis and experimental validation (in vitro and in vivo) as described in the document.

Freshness

Last updated 2026-05-22 06:09:53; freshness should be verified.