Neutrophil-to-Lymphocyte Ratio and Snakebite Severity in 203 Patients

A retrospective cohort study of 203 patients with confirmed Gloydius brevicaudus snakebite envenomation. It analyzes the dose-response association between admission neutrophil-to-lymphocyte ratio (NLR) and clinical severity, dichotomized as mild or moderate-to-severe. The research was conducted by Yu-hong Wang and includes multivariable logistic regression models adjusting for demographic and bite-related factors.

Use Cases

• Analyze the dose-response relationship between admission NLR values and the dichotomized clinical severity score.
• Build logistic regression models using NLR, demographic factors, and bite-related factors to predict moderate-to-severe envenomation risk.
• Examine quartile-based trends in NLR to identify thresholds associated with a nearly fourfold increased risk of severe outcomes.
• Investigate the association of NLR with other clinical characteristics like infection status and leukocytosis.

Strengths

• Includes data from 203 patients with confirmed snakebite envenomation for analysis.
• Provides specific statistical results, including an adjusted odds ratio of 3.94 for the highest NLR quartile.
• Clinical severity is assessed using a defined bedside score based on clinical manifestations.

Limitations

• The dataset is contained within a 2.3 MB DOC file, which is a small, non-tabular format unsuitable for direct computational analysis.
• The underlying raw data (rows, columns, sample data) is unavailable, limiting reproducibility and secondary analysis.
• As a retrospective cohort study from a single context, findings may have geographic or clinical practice biases.

Provenance

Source

Yu-hong Wang, published on figshare.

Collection Method

Retrospective cohort study of hospital patients.

Freshness

Last updated on 2026-03-25.