Data Sheet 2_DPP4 inhibition affects metabolism and inflammation associated pathways in hi

Christiane Loerch published transcriptomic data from a human induced pluripotent stem cell (iPSC)-derived hepatocyte-like cell (HLC) model of metabolic dysfunction-associated steatotic liver disease (MAFLD). The dataset, last updated in March 2026, contains results from experiments where steatosis was induced by oleic acid feeding and DPP4 activity was inhibited with vildagliptin (VILDA). It includes global transcriptomic analyses and secretome data to study disease-associated pathways and drug effects.

Use Cases

• Analyze differential gene expression in PPAR and TNF signaling pathways based on transcriptomic data.
• Investigate the role of DPP4/CD26 in inflammation and metabolism pathways described in the study.
• Model the effects of vildagliptin inhibition on fatty acid and purine metabolism gene expression.
• Validate in vitro hepatocyte-like cell models for MAFLD/MASLD drug discovery research.

Strengths

• Data is associated with a specific, peer-reviewed research methodology using hiPSC-derived hepatocyte-like cells and NGS-based transcriptomics.
• Dataset is licensed under CC-BY-4.0, permitting broad reuse and redistribution.
• File size is 1.9 MB, indicating a manageable download and processing scale.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• Data is derived from a specific in vitro model system, which may not fully capture in vivo complexity.

Provenance

Source

Christiane Loerch via figshare.

Collection Method

Generated from in vitro experiments using human induced pluripotent stem cell-derived hepatocyte-like cells, oleic acid feeding, and vildagliptin treatment, followed by NGS-based transcriptomic analysis.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-03-18 07:43:59.

Geography

Spatial coverage is not specified; data is from a laboratory study.