Gut Microbiome and Mycobiome in Ulcerative Colitis Across Life Stages

Targeted metagenomic data from 73 bacterial and 69 fungal samples collected from 26 pediatric and 47 adult patients with ulcerative colitis. The dataset was created by Francesca Toto and published on figshare in April 2026. It includes microbial diversity metrics, immune marker measurements, and clinical variables to study age-related ecological patterns.

Use Cases

• Compare fungal versus bacterial community dynamics based on life-stage stratification mentioned in the description
• Identify taxa associated with inflammation or gut health based on the enrichment and depletion patterns described
• Investigate correlations between microbial abundance and mucosal immune markers like lysozyme and sIgA
• Model dysbiosis using metrics such as Basidiomycota/Ascomycota and Firmicutes/Bacteroidota ratios

Strengths

• Includes 142 total metagenomic samples (73 bacterial, 69 fungal) from a defined cohort of 73 patients
• Integrates microbial data with clinical variables (disease activity, duration, treatment) and immune marker measurements
• Explicitly stratifies analysis by life stage (pediatric vs. adult), with a focus on young adults

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• Sample size of 73 patients may limit statistical power for subgroup analyses
• Data is contained within a 1.6 MB PDF, which may require extraction and structuring for computational analysis

Provenance

Source

figshare, author Francesca Toto

Collection Method

Targeted metagenomic sequencing of gut samples from ulcerative colitis patients, with subsequent bioinformatic and statistical analysis.

Freshness

Last updated 2026-04-28 05:28:21