Chromosome 9 Inversion and IVF Outcomes Propensity Score Study

Wenjie Huang's research dataset analyzes 40,502 assisted reproductive technology (ART) cycles from September 2008 to December 2023. It compares reproductive outcomes for 903 couples with pericentric inversion of chromosome 9 against 39,599 couples with normal karyotypes using propensity score matching.

Use Cases

• Compare live birth rate (LBR) outcomes between inv(9) and normal karyotype groups in fresh embryo transfer cycles.
• Analyze secondary outcomes like miscarriage, multiple births, and low birth weight among live births across the matched cohorts.
• Evaluate cycle parameters such as oocyte yield, fertilization rate, and blastocyst formation rate between the study groups.
• Investigate differences in clinical pregnancy and biochemical pregnancy outcomes for male versus female inv(9) carriers.

Strengths

• Dataset covers 40,502 ART cycles, providing a substantial sample for analysis.
• Study employs propensity score matching to balance baseline characteristics between the 903 inv(9) and 39,599 control cycles.
• Temporal coverage spans over 15 years, from September 2008 to December 2023.

Limitations

• Underlying data is not provided in a structured, tabular format (e.g., CSV); analysis is presented in a DOCX document.
• Sample size for the inv(9) carrier group (903 cycles) is smaller than the control group, potentially limiting statistical power for some subgroup analyses.
• Geographic origin of the data is unspecified, which may limit generalizability.

Provenance

Source

Wenjie Huang via figshare.

Collection Method

Retrospective cohort study of clinical ART cycles.

Time Range

September 2008 to December 2023.

Freshness

Data current through December 2023, with the document last updated in March 2026.

Geography

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