Neurotoxicity Mechanisms of Dioctyl Terephthalate: 90 Targets and In Vivo Validation

A 618-byte CSV file published on figshare by Hao Tang on April 10, 2026. It contains results from a study investigating the neurotoxicity of the plasticizer DOTP, integrating network toxicology, molecular dynamics simulations, and in vivo experiments. The data likely includes identified protein targets, binding affinities, and pathway enrichment analysis results.

Use Cases

• Validate network toxicology predictions based on the 90 identified neurotoxicity-related targets.
• Analyze protein-protein interaction networks based on core nodes like EGFR, BCL2, and CASP3.
• Study pathway enrichment based on Gene Ontology (GO) and KEGG analyses mentioned in the description.
• Correlate computational docking scores with in vivo neurofunctional deficits and neuronal loss findings.

Strengths

• Data is derived from an integrated methodology combining computational prediction and in vivo validation.
• Results are focused on 90 specific neurotoxicity-related targets and 7 core nodes (e.g., EGFR, BCL2).
• Published under a permissive CC-BY-4.0 license allowing reuse.

Limitations

• Dataset is extremely small (618 bytes), indicating very limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Hao Tang.

Collection Method

Generated via computational modeling (network toxicology, molecular docking, dynamics simulations) and in vivo mouse experiments.

Time Range

Study publication date is 2026.

Freshness

Last updated 2026-04-10 05:58:48; freshness should be verified.

Geography

Geographic scope of the data collection is not specified.