Exercise and Inflammation Meta-Analysis Data for Overweight Postmenopausal Women

30 randomized controlled trials (N = 2,124) were analyzed to evaluate the dose-response effects of exercise on inflammatory biomarkers in overweight and obese postmenopausal women. The dataset, created by Gang Huang and last updated in March 2026, contains meta-analysis results from a systematic search of five databases up to January 2026. It includes standardized mean differences for biomarkers like CRP and TNF-α, with meta-regression results for exercise volume, duration, and intensity.

Use Cases

• Conducting secondary meta-regression analysis based on reported exercise intensity (%HRmax) and biomarker outcomes.
• Investigating the relationship between exercise volume (MET-minutes/week) and inflammatory markers like CRP and TNF-α.
• Validating the 'intensity threshold' hypothesis for anti-inflammatory adaptations in postmenopausal obesity.
• Comparing the stability of effect sizes for different inflammatory biomarkers using the provided sensitivity analysis results.

Strengths

• Analysis is based on 30 randomized controlled trials, a substantial number for a meta-analysis.
• Results show statistically significant reductions in TNF-α (SMD = -0.47) and CRP (SMD = -0.36).
• Leave-one-out sensitivity analyses confirmed stable effect size ranges for key biomarkers.
• Exercise parameters like intensity were systematically standardized to %HRmax for comparability.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for some analytical purposes.
• The dataset is very small (14.5 KB), indicating limited raw data or summary-level results only.

Provenance

Source

figshare, author Gang Huang

Collection Method

Systematic review and meta-analysis of five databases for randomized controlled trials.

Time Range

Studies up to January 2026 were included in the search.

Freshness

Last updated 2026-03-19 05:17:29