Murine Sepsis-Lung Injury Data: Endothelial vs. Neutrophil PD-L1 Knockout Impact

Elizabeth W. Tindal's 2026 study provides experimental data on the role of programmed cell death receptor-ligand 1 (PD-L1) in shock/sepsis-induced lung injury. The dataset includes mortality rates, lung permeability measurements, and cytokine/chemokine/angiopoietin levels from bronchoalveolar lavage fluid, lung tissue, and blood of genetically modified mice. Results indicate a morbid impact from endothelial cell PD-L1 loss but a potential protective role from neutrophil PD-L1 expression.

Use Cases

• Modeling mortality risk based on cell-specific PD-L1 knockout status in murine sepsis.
• Analyzing correlations between lung vascular permeability and cytokine levels like MCP-1 and IL-6.
• Comparing biomarker profiles (Angiopoietin 2, MIP-2, BUN) across different genetic mouse models subjected to hemorrhagic shock and CLP.

Strengths

• Data is derived from controlled Cre-lox mouse models allowing cell-type-specific genetic analysis.
• Includes multiple biological sample types: peripheral blood, bronchoalveolar lavage fluid, and lung tissue.
• Measures a range of biological endpoints: survival, vascular permeability, and protein concentrations via ELISA and flow cytometry.

Limitations

• The dataset is small (310.5 KB), suggesting limited scope or aggregated summary statistics rather than raw experimental records.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale ML tasks.

Provenance

Source

Elizabeth W. Tindal via figshare.

Collection Method

Experimental data from murine models subjected to hemorrhagic shock and cecal ligation and puncture (CLP).

Freshness

Last updated 2026-06-02 04:31:27.