Murine Shock/Sepsis Lung Injury Data on PD-L1 Knockout Impact

Experimental data from a study using Cre-lox mouse models to test the role of programmed cell death receptor-ligand 1 (PD-L1) in shock/sepsis-induced lung injury. The dataset includes survival rates, lung permeability measurements, and cytokine, chemokine, and angiopoietin levels from blood, bronchoalveolar lavage fluid, and lung tissue. Authored by Elizabeth W. Tindal and shared under a CC-BY-4.0 license, the data was last updated in June 2026.

Use Cases

• Compare survival outcomes based on endothelial cell versus neutrophil PD-L1 deficiency mentioned in the description
• Analyze correlations between lung vascular permeability and cytokine levels described in the results
• Model the differential impact of PD-L1 loss on specific biomarkers like MCP-1, Angiopoietin 2, MIP-2, and IL-6
• Validate hypotheses about the morbid versus protective roles of PD-L1 expression in different cell types during sepsis

Strengths

• Data is derived from controlled Cre-lox mouse models allowing cell-type-specific genetic knockout studies.
• Includes multiple biological measurements: survival, lung permeability, and cytokine/chemokine/angiopoietin levels from three sample types.
• Shared under a permissive CC-BY-4.0 license for reuse and redistribution.

Limitations

• Dataset size is 310.5 KB, indicating a limited scope and likely small sample size.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale statistical modeling.

Provenance

Source

Elizabeth W. Tindal via figshare.

Collection Method

Data generated from laboratory experiments on C57BL/6, ecPD-L1−/−, and pmnPD-L1−/− mice subjected to hemorrhagic shock and cecal ligation and puncture (CLP) or sham procedures.

Freshness

Last updated 2026-06-02 04:28:47; freshness should be verified.