Data Sheet 2: SIRT3 Interaction and Cardiac Mitochondrial Data

SA-22, a synthetic analog of a cardioprotective fatty acid metabolite, was found to be a positive allosteric modulator of the mitochondrial protein SIRT3. This dataset likely contains results from thermal shift assays, fluorogenic activity measurements, and cell-based assays of mitophagy and respiration under hypoxic injury. The data was authored by Joshua W. Kranrod and shared under a CC-BY-4.0 license in June 2026.

Use Cases

• Modeling the allosteric modulation of SIRT3 based on thermal shift assay data
• Analyzing the impact of SA-22 on mitochondrial respiration rates under hypoxia-reoxygenation conditions
• Studying changes in mitophagy flux in cardiac cells treated with fatty acid analogs

Strengths

• Data is associated with a peer-reviewed research methodology described in detail.
• The 14.5 MB file size suggests a focused, potentially well-structured experimental dataset.
• License is clearly defined as CC-BY-4.0, permitting broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.
• The dataset's scope is limited to in vitro and cellular models described in the associated study.

Provenance

Source

Joshua W. Kranrod via figshare

Collection Method

Generated from laboratory experiments including thermal shift assays, fluorogenic activity assays, point mutagenesis, and cell culture models.

Freshness

Last updated 2026-06-02 04:21:33; freshness should be verified.