E. coli Urinary Tract Infection Model Data from Göttingen Minipigs

A study establishing a 14-day intraurethral urinary tract infection model in Göttingen minipigs using uropathogenic E. coli strain UTI89. The dataset, authored by Joyce Lübbers and last updated in May 2026, includes results from bacterial enumeration, agglutination tests, and whole genome sequencing of recovered strains. It reports that 75% of animals were infected with the challenge strain, while 25% had a different E. coli strain.

Use Cases

• Evaluating vaccine efficacy based on the described minipig UTI model.
• Assessing antibiotic treatment outcomes using the bacterial enumeration and strain recovery data.
• Studying bacterial strain persistence and identity verification based on the whole genome sequencing results.
• Bridging preclinical findings to human clinical outcomes based on the model's stated purpose.

Strengths

• Includes whole genome sequencing data for bacterial strain characterization.
• Reports specific infection rates: 75% with the challenge strain and 25% with a different strain.
• Describes a 14-day infection model, providing a defined experimental timeframe.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 752.1 KB DOCX document, which may not be in a readily analyzable structured format.

Provenance

Source

figshare

Collection Method

Data generated from an experimental study involving intraurethral challenge of minipigs with E. coli, followed by urine collection, bacterial plating, agglutination testing, and sequencing.

Freshness

Last updated 2026-05-18 05:45:02; freshness should be verified.