Data Sheet 2: Neutrophil Extracellular Trap Markers in Major Depressive Disorder

Two independent clinical cohorts (Cohort 1: n=83; Cohort 2: n=60) and a mouse model were used to evaluate three neutrophil extracellular trap (NET) markers for diagnosing major depressive disorder (MDD) and predicting treatment response. The dataset, authored by Yachen Shi and last updated on May 12, 2026, contains plasma measurements of myeloperoxidase-DNA, neutrophil elastase-DNA, and citrullinated histones. Results indicate plasma NET markers were significantly higher in MDD patients and could predict changes in depression rating scale scores after treatment.

Use Cases

• Diagnostic model development based on plasma levels of NET markers (MPO-DNA, NE-DNA, citH3).
• Predicting treatment response in MDD based on correlations between NET markers and Hamilton Depression Rating Scale scores.
• Investigating inflammatory mechanisms in depression based on the relationship between NETs and C-reactive protein.
• Validating animal models of depression by comparing hippocampal NET levels in CUMS mice with human plasma data.

Strengths

• Data is validated across two independent clinical cohorts totaling 143 participants.
• Includes results from a chronic unpredictable mild stress (CUMS) mouse model for cross-species comparison.
• License is CC-BY-4.0, allowing for broad reuse and sharing.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (11.3 KB), indicating limited scope.

Provenance

Source

figshare, authored by Yachen Shi.

Collection Method

Plasma samples were collected from two clinical cohorts; NET markers were measured. Hippocampal NET levels were detected in a CUMS mouse model.

Freshness

Last updated 2026-05-12 04:19:01; freshness should be verified.