FGFR2/STAT3 Signaling in MMTV-Related Spontaneous Breast Cancer in TA2 Mice

Jiaxing Du's research dataset investigates the FGFR2/STAT3 signaling pathway in spontaneous breast cancer development in TA2 mice. The study includes data on protein expression levels (FGF3, FGFR2, STAT3, p-STAT3) in mouse serum and tissues across different pregnancy counts, as well as cell line (MA-891) experiments and analysis of 139 human breast cancer cases. The dataset was last updated on 2026-05-13.

Use Cases

• Analyze the correlation between pregnancy count and MMTV-LTR amplification/FGFR2/STAT3 expression based on the described mouse tissue data.
• Investigate the effects of STAT3 inhibition on cancer cell proliferation, invasiveness, and migration based on the MA-891 cell line experiments.
• Compare STAT3 expression levels between triple-negative and non-triple-negative human breast cancer based on the 139-case human sample analysis.
• Study downstream protein expression (Bcl2, cyclin D1, c-myc) in response to STAT3 pathway modulation based on the described xenograft and cell line data.

Strengths

• Includes data from a specific mouse model (TA2) with high incidence of spontaneous breast cancer.
• Analyzes a substantial human sample cohort of 139 breast cancer cases.
• Investigates multiple biological levels: serum, tissue, cell line, and xenograft models.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 38.5 KB, indicating limited scope.

Provenance

Source

Jiaxing Du

Collection Method

Experimental data from mouse model studies, cell line assays, and human tissue analysis.

Freshness

Last updated 2026-05-13 10:35:19; freshness should be verified.