Data Sheet 2_Functional and genetic divergence of aging-related TOMM40 polymorphisms in Al

A 618.6 KB document by Shiqi Li, last updated April 10, 2026, containing results from a systematic review and meta-analysis of thirteen articles. It assesses the association of six TOMM40 polymorphisms with Alzheimer's disease risk, integrating genome-wide, regulatory, and functional genomic evidence.

Use Cases

• Assessing genetic risk associations for Alzheimer's disease based on six TOMM40 polymorphisms.
• Conducting pathway enrichment analysis based on lipid- and amyloid-related gene expression evidence.
• Investigating linkage disequilibrium and regulatory patterns in the APOE–TOMM40–APOC1 locus.
• Performing trial sequential analysis for genetic association studies based on the described methodology.

Strengths

• Integrates evidence from a meta-analysis of thirteen articles.
• Includes bioinformatic analysis from multiple sources: IGAP/NIAGADS genome-wide data, AGORA functional annotations, and GTEx regulatory evidence.
• Assesses six specific polymorphisms (rs2075650, rs157580, rs157581, rs8106922, rs11556505, rs1160985) across five genetic models.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 618.6 KB DOCX file, indicating a limited scope focused on analysis results rather than raw genetic data.

Provenance

Source

figshare, author Shiqi Li.

Collection Method

Comprehensive literature search across five electronic databases, meta-analysis using RevMan 5.1, and integration of public genomic datasets.

Time Range

Temporal coverage of the included studies is not specified.

Freshness

Last updated 2026-04-10 05:58:20; freshness should be verified.

Geography

Spatial coverage is not specified.