Galectin-3-FBXL5-YAP1 Axis in Colorectal Cancer: Research Findings and Data

A research document by Xiang Zeng, last updated in April 2026, details a study on the molecular mechanisms of colorectal cancer. The 1.3 MB file presents findings on the Galectin-3-FBXL5-YAP1 signaling axis, which may constrain tumor growth. The study integrated TCGA and single-cell RNA sequencing data and performed molecular and functional assays.

Use Cases

• Study the clinical relevance of LGALS3 and FBXL5 expression based on survival correlations mentioned in the description
• Investigate protein degradation mechanisms based on the described Gal-3-FBXL5-YAP1 ubiquitination pathway
• Validate antitumor signaling axes based on the described cell proliferation and xenograft model results

Strengths

• File size is 1.3 MB, indicating a detailed document.
• The description provides a specific mechanistic conclusion about a Gal-3-FBXL5-YAP1 regulatory axis.
• The study integrated data from TCGA and single-cell RNA sequencing sources.

Limitations

• The primary data file is a DOCX document, not a structured dataset; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• The description notes that additional validation experiments are required to strengthen the causal framework.

Provenance

Source

figshare

Collection Method

Integrated analysis of TCGA and single-cell RNA sequencing data, supplemented by molecular and functional assays.

Freshness

Last updated 2026-04-21 05:24:26