Data Sheet 2_Genetic variants of CD160, MERTK, and IL15 in natural killer cell-related pat

2,211 Chinese gastric cancer patients from a Shanghai GWAS were used to evaluate 12,476 SNPs in 151 NK cell-related genes for associations with overall survival. The study, authored by Guang Zeng and published on figshare in 2026, identified three independent SNPs (CD160 rs9728526, MERTK rs114788905, IL15 rs140007893) validated in an independent cohort of 1,049 patients.

Use Cases

• Build survival prediction models based on the three identified SNPs (CD160 rs9728526, MERTK rs114788905, IL15 rs140007893).
• Analyze associations between NK cell-related genetic variants and immune cell infiltration in the tumor microenvironment.
• Validate prognostic biomarkers for gastric cancer using the hazard ratios and confidence intervals provided.
• Conduct functional enrichment analyses based on the expression QTL, splicing QTL, and transcription factor binding annotations described.

Strengths

• Data is derived from a genome-wide association study with a total of 3,260 patients across two independent Chinese cohorts.
• The analysis evaluated a large number of genetic variants, specifically 12,476 SNPs across 151 genes.
• Statistical validation includes hazard ratios, confidence intervals, and metrics like C-index, NRI, and IDI.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's primary file format is DOCX, which may require conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Genome-wide association study (GWAS) analysis of patient cohorts.

Time Range

The study period is not specified in the input.

Freshness

Last updated 2026-04-15 05:41:32; freshness should be verified.

Geography

China (Shanghai and Jiangsu cohorts).