Genome-Wide Gene Expression Data for Primary Sjögren's Syndrome

A 2026 study by Zhongshan Li presents gene expression data from 126 minor salivary gland samples, including 92 from patients with primary Sjögren's syndrome and 34 from non-SS controls. The dataset includes results from deep stranded total transcriptome sequencing, differential expression analysis, and a constructed genome-wide competing endogenous RNA network. The research identifies and validates regulatory roles for specific long non-coding RNAs in the disease.

Use Cases

• Constructing competing endogenous RNA (ceRNA) networks based on shared miRNA binding sites and gene expression correlations.
• Identifying differentially expressed genes between pSS and control groups for biomarker discovery.
• Investigating the regulatory roles of specific lncRNAs like BISPR, LINC00926, and HCP5 in autoimmune pathways.
• Validating in silico predictions of lncRNA function through correlation with clinical features.

Strengths

• Includes data from 126 human tissue samples, providing a substantial biological cohort.
• Features a constructed genome-wide ceRNA network comprising 3,035 lncRNAs and 10,838 coding genes.
• Regulatory roles for three key lncRNAs were validated by in vitro experiments.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 709.6 KB PDF, suggesting the underlying numerical data may be summarized or embedded in figures rather than provided as a raw, machine-readable table.

Provenance

Source

figshare, author Zhongshan Li.

Collection Method

Deep stranded total transcriptome sequencing of minor salivary gland biopsies.

Time Range

The study and data were published in 2026.

Freshness

Last updated 2026-04-15 05:33:16.

Geography

Geography is not specified in the provided metadata.