Laron Mouse Liver RNA-seq Data on Growth Hormone Receptor Gene Therapy

448 genes showed significant expression changes in livers of GH-resistant mice treated with a liver-specific GHR gene therapy compared to a luciferase control. The dataset contains RNA-seq results from male and female mice across wild-type, GHR-deficient (Laron), treated, and control groups, published by Joshua K. Tay on figshare in 2026. It includes differential expression analysis for 2781 genes altered in GHR-deficient mice and details on the upregulation of IGF signaling genes.

Use Cases

• Analyze the effects of growth hormone receptor gene therapy based on RNA-seq data from treated mouse livers.
• Investigate sex-biased gene expression in the liver based on the enrichment analysis mentioned in the description.
• Compare gene expression profiles between wild-type and GHR-deficient (Laron) mouse models.
• Study the response of IGF signaling genes (Igf1, Igfals) to gene therapy based on the reported ~16-fold upregulation.

Strengths

• Includes data from four distinct experimental groups (wild-type, knockout, treated, control) for comparison.
• Reports specific fold-change values (e.g., ~16-fold for Igf1) and gene counts (448, 2781) for differential expression.
• Explicitly controls for vector effects with a luciferase-treated control group, noting minimal impact.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (813.6 KB), suggesting limited scope, likely summary statistics rather than raw sequence reads.

Provenance

Source

figshare

Collection Method

RNA-seq performed on livers from genetically engineered mouse models following adeno-associated virus (AAV) gene therapy.

Freshness

Last updated 2026-05-28 04:56:30; freshness should be verified.