Jingui He published a research dataset on figshare in May 2026. The dataset likely contains results from Mendelian randomization, transcriptomics, and single-cell RNA sequencing analyses related to GPX7 in ulcerative colitis. The file is a PDF of 136.4 KB.
Use Cases
- Validate GPX7 as a genetic candidate in ulcerative colitis based on Mendelian randomization and cis-pQTL support.
- Analyze stromal-innate immune crosstalk based on single-cell RNA sequencing localization of GPX7 to a fibroblast state.
- Investigate fibroblast-macrophage co-culture responses based on transcriptomic data from a Transwell system.
- Explore candidate modulator QL-X-138 based on docking and molecular dynamics analyses.
- Correlate GPX7 expression with clinical outcomes based on data from an infliximab-stratified cohort.
Strengths
- Data is derived from multiple orthogonal methods, including Mendelian randomization, transcriptomics, and single-cell RNA sequencing.
- Results were validated in an independent clinical cohort and a fibroblast-macrophage co-culture model.
- The dataset is openly licensed under CC-BY-4.0.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is a single PDF file of 136.4 KB, suggesting limited scope.
Provenance
- Source
- figshare
- Collection Method
- Integrated analysis of Mendelian randomization, transcriptomics, and single-cell RNA sequencing.
- Freshness
- Last updated 2026-05-22 04:30:49; freshness should be verified.