Hypoxia Inducible Factor 1 Alpha and Autophagy in Oral Lichen Planus Cell Model

A 128.9 KB PDF research article investigates the role of the HIF-1α transcription factor in autophagy dysfunction within a simulated oral lichen planus inflammatory cell model. Author Xie Li published the work on figshare under a CC-BY-4.0 license, with a last update recorded for April 14, 2026. The study includes mechanistic findings from cell models and C. elegans experiments, linking HIF-1α expression to impaired lysosomal degradation.

Use Cases

• Analyze gene expression patterns based on HIF1A mRNA up-regulation data mentioned in the description.
• Study autophagy impairment based on the described abnormal accumulation of LC3-II and p62 marker proteins.
• Investigate therapeutic targets based on the described effect of HIF-1α knockdown on restoring autophagy function.
• Model cellular damage pathways based on the described link between HIF-1α, lysosomal gene inhibition, and cell activity.

Strengths

• Data is openly shared under a permissive CC-BY-4.0 license.
• The 128.9 KB file size indicates a focused, downloadable research document.
• The description provides specific biological findings, including results from C. elegans experiments.

Limitations

• The dataset is a single PDF research article, not a structured data table for direct computational analysis.
• Row count and column-level documentation are absent; data semantics must be extracted manually from the text.
• The 128.9 KB size indicates a very limited scope, containing only the described study's findings.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from a controlled laboratory study comparing control and model groups.

Freshness

Last updated 2026-04-14 04:21:24; freshness should be verified.