Common Genes in Diabetic Nephropathy and Retinopathy from Transcriptome Analysis

206 common genes were identified by intersecting differentially expressed genes from diabetic nephropathy and diabetic retinopathy transcriptome data. The study, authored by Juan He and last updated in April 2026, screened 6 diagnostic genes for DN and 4 for DR, including ATP4A which is common to both. It further constructed TF-mRNA-miRNA regulatory networks and analyzed immune cell infiltration differences between the conditions.

Use Cases

• Identify potential diagnostic biomarkers for diabetic nephropathy based on the 6 screened genes (METTL27, NMNAT2, TTC25, GAS6, ATP4A, ZNF223).
• Investigate shared molecular pathways between diabetic complications using the 206 common genes.
• Analyze immune cell infiltration patterns in diabetic nephropathy and retinopathy, such as the decreased proportion of central memory CD4 T cells in DN.
• Study transcriptional regulation by exploring the constructed TF-mRNA-miRNA networks, including the key TF EGR1.

Strengths

• Identifies a specific set of 206 common genes between two diabetic complications.
• Screens a defined number of diagnostic genes: 6 for diabetic nephropathy and 4 for diabetic retinopathy.
• Includes analysis of immune cell infiltration and constructed regulatory networks (e.g., 493 TF-6mRNA-183miRNA for DN).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 168.7 KB, indicating limited scope.

Provenance

Source

figshare, author Juan He.

Collection Method

Analysis of transcriptome data GSE185011 using differential expression analysis (limma), enrichment analysis, LASSO, and network construction.

Freshness

Last updated 2026-04-28 05:24:43; freshness should be verified.