Imaging Mass Cytometry of the Immune Microenvironment in Alveolar Echinococcosis

Sixteen immune cell types were resolved in liver tissue from six patients with alveolar echinococcosis. The dataset, created by Yanyan Ma and last updated in May 2026, provides a spatially resolved map of immune cell infiltration, checkpoint expression, and microenvironment architecture. It includes comparisons between lesion-proximal and lesion-distal regions and between pediatric and adult patients.

Use Cases

• Classifying immune microenvironment subtypes based on spatial cell distributions described in the results.
• Analyzing myeloid–lymphoid crosstalk and T cell exhaustion based on correlations between M2 macrophages and T cells.
• Studying immune checkpoint molecule expression patterns, including PD-1/PD-L1 co-expression and CD47 distribution.
• Comparing age-related differences in immune response based on neutrophil densities in pediatric versus adult patients.

Strengths

• Data is derived from high-dimensional imaging mass cytometry, enabling simultaneous profiling of multiple features.
• Includes tissue from six patients with histologically confirmed disease, providing a human clinical basis.
• Enables spatial analysis by comparing lesion-proximal and lesion-distal regions within liver sections.

Limitations

• The dataset is small in file size (87.0 KB), suggesting it may be a summary document rather than the primary image data.
• Column-level documentation and sample data are unavailable, requiring manual inspection after download.
• Row count and the exact number of tissue samples or images are unknown, limiting suitability assessment.

Provenance

Source

figshare, authored by Yanyan Ma.

Collection Method

Imaging mass cytometry performed on liver tissue sections from six patients, with complementary immunofluorescence and immunohistochemistry.

Freshness

Last updated 2026-05-08 05:56:03; freshness should be verified.