Meta-Analysis on Hypertension and Cognitive Impairment in Atrial Fibrillation Patients

A systematic review and meta-analysis of 20 observational studies involving 998,622 atrial fibrillation patients, conducted by Xingxing Mi and published on figshare in 2026. It evaluates the association between a history of hypertension, blood pressure parameters, and the risk of cognitive impairment. The analysis includes data from eight databases searched from their inception to September 7, 2025.

Use Cases

• Estimating the association between hypertension history and cognitive impairment risk based on reported odds ratios.
• Analyzing the impact of high-normal blood pressure levels on cognitive outcomes in atrial fibrillation patients.
• Conducting subgroup analyses on specific cognitive impairment types like mild cognitive impairment or dementia.
• Assessing study quality and heterogeneity in observational research on cardiovascular and neurological comorbidity.

Strengths

• Includes data from 20 studies with a total of 998,622 patient records.
• Reports specific statistical results, including an odds ratio of 2.22 for hypertension history and overall cognitive impairment.
• Uses established quality assessment tools (NOS and AHRQ) and reports heterogeneity statistics (I²).
• Has a registered systematic review protocol (PROSPERO CRD420251186104).

Limitations

• The primary data file is a 268.7 KB DOCX document, which is a small text summary rather than a raw dataset.
• Row count and column-level documentation for underlying study data are unknown.
• The dataset's utility for direct machine learning is limited as it contains aggregated meta-analysis results, not patient-level records.

Provenance

Source

figshare, author Xingxing Mi.

Collection Method

Systematic review and meta-analysis of observational studies from eight databases.

Time Range

Studies from database inception to September 7, 2025.

Freshness

Last updated 2026-06-02 05:42:17.