Stress Hyperglycemia Ratio and Stroke Outcomes in 36 Thrombolysis Centers

A population-based study analyzes the relationship between Stress Hyperglycemia Ratio (SHR) and functional outcomes for ischemic stroke patients treated with intravenous thrombolysis. The research, conducted by Danhui Li, enrolled patients from 36 centers and identified a non-linear threshold effect at an SHR of 1.09. The dataset includes clinical parameters such as glucose, glycated hemoglobin (HbA1c), and modified Rankin Scale scores at 90 days.

Use Cases

• Investigate the non-linear relationship between the calculated Stress Hyperglycemia Ratio (SHR) and 90-day modified Rankin Scale scores using piecewise regression.
• Assess the predictive value of SHR for poor functional outcomes, stratified by demographic factors like BMI < 25 kg/m² and HbA1c < 6.5%.
• Validate the identified inflection point at SHR = 1.09 as a risk stratification indicator for stroke patients receiving thrombolytic therapy.
• Perform sensitivity analyses on clinical subgroups, such as non-diabetic patients, using multivariable logistic regression models.

Strengths

• Data sourced from a multi-center study involving 36 clinical centers, providing a broad patient base.
• Analysis identifies a specific, statistically significant inflection point at SHR = 1.09 for outcome prediction.
• Study adjusts for a range of demographic, clinical, and laboratory parameters in its models.

Limitations

• The underlying patient-level data is not provided; the dataset consists of an 8.5 KB PDF summarizing study results.
• The retrospective study design may introduce selection bias compared to a prospective trial.
• Sample size and specific row/column counts for the original clinical data are unknown.

Provenance

Source

Danhui Li via figshare.

Collection Method

Retrospective enrollment of ischemic stroke patients treated with intravenous thrombolysis.

Freshness

Last updated in March 2026.

Geography

Population-based study across 36 centers; specific geographic region not stated.