Gut Microbiota and Metabolite Associations with Oral Cancer via Mendelian Randomization

A 2026 analysis by Junfeng Guo investigates causal links between gut microbiota, circulating metabolites, and oral cancer using Mendelian randomization. The study uses summary statistics from genome-wide association studies for 471 gut microbial taxa, 233 circulating metabolites, and oral cancer. Findings include 35 causal microbial associations and 20 metabolite associations, with clinical multi-omics validation.

Use Cases

• Identify potential causal gut microbial taxa for oral cancer risk based on reported odds ratios.
• Investigate mediating roles of specific circulating metabolites like citrate and omega-3 fatty acids.
• Validate Mendelian randomization findings using independent clinical multi-omics profiling data.
• Explore genetic instruments for gut microbiota and metabolites derived from large-scale GWAS.

Strengths

• Analysis is based on summary statistics from large-scale GWAS for 471 microbial taxa and 233 metabolites.
• Employs multiple Mendelian randomization methods (IVW-MR, GSMR) and reports checks for pleiotropy and heterogeneity.
• Includes clinical validation samples to support the genetic findings.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 3.0 MB DOCX document, which may not be in a standard analysis-ready format.

Provenance

Source

Summary statistics from genome-wide association studies (GWAS), author Junfeng Guo.

Collection Method

Bidirectional two-sample Mendelian randomization analysis with clinical validation.

Freshness

Last updated 2026-05-21 05:45:51; freshness should be verified.