TP53 H179 Mutation Analysis in NSCLC: Structural and Genomic Characterization

A 2026 study by Ankur Datta analyzes TP53 gene mutations at the His179 zinc-binding site in 1,160 Non-Small Cell Lung Cancer (NSCLC) patients from TCGA. The research, published on figshare, combines genomic profiling with molecular dynamics simulations to assess structural and functional impacts of specific amino acid substitutions. The dataset includes results on mutation prevalence, conformational signatures, and binding affinity changes for five H179 variants.

Use Cases

• Benchmarking molecular dynamics simulation results based on conformational trajectory analysis described in the study
• Investigating genotype-structure-function relationships in TP53 based on the identified H179 (Y/R/N/L/D) substitutions
• Analyzing mutation prevalence and patterns in NSCLC subtypes based on the TCGA cohort data for 616 LUAD and 544 LUSC individuals
• Studying zinc-binding motif integrity in metalloproteins based on the evaluated binding affinity values for p53 mutants

Strengths

• Includes data from 1,160 NSCLC patients (616 LUAD, 544 LUSC) from TCGA
• Provides specific mutation prevalence statistics: TP53 mutations in 50% of LUAD and 81% of LUSC cases
• Analyzes five distinct H179 variants (Y/R/N/L/D) with structural and binding affinity evaluations

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is contained in a DOCX file (122.0 KB), suggesting a limited, text-based report rather than a raw data table

Provenance

Source

TCGA (The Cancer Genome Atlas) mutational profiles, analyzed by author Ankur Datta

Collection Method

Genomic evaluation combined with static structural analysis and atomistic molecular dynamics simulations (MDS)

Time Range

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Freshness

Last updated 2026-04 10 05:59:19

Geography

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