Plasma Exosomal Proteomics Data for Thyroid Disorders and Papillary Thyroid Carcinoma

Yawei Zhang's research dataset contains proteomic profiles of plasma-derived exosomes from patients with papillary thyroid carcinoma (PTC), PTC with Hashimoto’s thyroiditis (PTC-W), Hashimoto’s thyroiditis (HT), and healthy controls. The data includes results from label-free quantitative proteomics identifying 45 differentially expressed proteins, validated via parallel reaction monitoring. The dataset was last updated on 2026-05-25.

Use Cases

• Identify candidate protein biomarkers for papillary thyroid carcinoma based on exosomal protein expression.
• Investigate the molecular link between Hashimoto’s thyroiditis and thyroid cancer progression using differential protein expression data.
• Validate proteomic discoveries via parallel reaction monitoring (PRM) data for proteins like SVEP1 and IGKV3-7.
• Perform functional enrichment analysis on proteins implicated in extracellular matrix–receptor interactions and immune response pathways.

Strengths

• Includes data from a controlled study with samples from four distinct patient groups (PTC, PTC-W, HT, HCs).
• Integrates discovery-phase proteomics with validation-phase parallel reaction monitoring (PRM) data.
• Identifies 45 differentially expressed proteins between key comparison groups.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (167.2 KB), indicating limited scope.

Provenance

Source

Yawei Zhang via figshare

Collection Method

Exosome isolation and label-free quantitative proteomics from patient plasma samples.

Freshness

Last updated 2026-05-25 04:45:00; freshness should be verified.