Integrative Multi-Omics Analysis of SNRPE in Uterine Corpus Endometrial Carcinoma

146.3 KB of supplementary data from a 2026 figshare study by Minyue Cao. The dataset supports research identifying the small nuclear ribonucleoprotein polypeptide E (SNRPE) as a key driver gene in uterine corpus endometrial carcinoma (UCEC). It likely contains results from GWAS, sQTL, eQTL, RNA-seq, and scRNA-seq analyses linking SNRPE to tumor progression and immune evasion.

Use Cases

• Validate prognostic biomarkers for UCEC based on the identified SNRPE gene.
• Study the relationship between splicing dysregulation and immune evasion based on the described scRNA-seq findings.
• Analyze the structural impact of alternative splicing events on oncogenic signaling pathways based on the described RNA-seq and motif analysis.
• Investigate correlations between gene expression and patient survival outcomes using the referenced TCGA-UCEC cohort data.

Strengths

• Data is openly available under a CC-BY-4.0 license.
• Analysis integrates multiple omics layers (GWAS, sQTL, eQTL, RNA-seq, scRNA-seq) as described in the methodology.
• Findings were validated using an independent clinical cohort and in vitro/in vivo assays.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (146.3 KB), indicating it is likely summary or supplementary results rather than raw sequencing data.

Provenance

Source

figshare, author Minyue Cao.

Collection Method

Integrative analysis of public genomic data (e.g., TCGA) combined with experimental validation, as described in the study.

Time Range

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Freshness

Last updated 2026-05-21 05:42:19; freshness should be verified.

Geography

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