HLA-DPA1/DPB1 Gene Expression in Pediatric Asthma Macrophages

HLA-DPA1 and HLA-DPB1 genes were identified as key downregulated immune checkpoint genes in pediatric asthma. This CSV file contains results from an integrative multi-omics analysis of bulk and single-cell RNA-seq data from patient samples and cell lines. Yuchen Wen published the data on figshare in June 2026 under a CC-BY-4.0 license.

Use Cases

• Validate identified key genes HLA-DPA1 and HLA-DPB1 based on the multi-omics analysis described.
• Investigate macrophage immune-metabolic dysregulation based on the described functional enrichment and pseudotime trajectory findings.
• Explore intercellular communication networks based on the described cell-cell communication analysis involving the MIF signaling axis.

Strengths

• Data integrates findings from multiple public datasets (GSE152004, GSE65204, GSE254127) and in vitro validation.
• Analysis employed four distinct machine learning algorithms (SVM-RFE, Boruta, LASSO, XGBoost) for candidate gene screening.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (540.0 B), indicating it likely contains summary results rather than raw expression data.

Provenance

Source

figshare

Collection Method

Integrative analysis of bulk and single-cell RNA-sequencing data from patient samples and cell lines.

Freshness

Last updated 2026-06-03 04:54:38; freshness should be verified.