Puerarin Treatment Effects in Vascular Dementia Rats: Behavioral and Molecular Data

Hongmei Tang published experimental data on figshare in 2026 investigating the therapeutic mechanism of Puerarin in vascular dementia. The dataset likely contains results from behavioral testing, histological staining, network pharmacology analyses, and molecular assays like ELISA, qPCR, and Western blotting. The ZIP file is 20.9 MB and is licensed under CC-BY-4.0.

Use Cases

• Validate network pharmacology predictions based on identified overlapping targets between Puerarin and vascular dementia.
• Analyze the correlation between cognitive performance and hippocampal neuronal injury based on behavioral testing and staining results.
• Model the inhibition of the TLR4/MyD88/NF-κB signaling pathway based on expression and phosphorylation data.
• Compare pro-inflammatory mediator levels before and after treatment based on experimental assay results.
• Assess the counteractive effect of a TLR4 agonist on therapeutic outcomes based on repeated behavioral and molecular analyses.

Strengths

• Dataset includes results from multiple validation methods: behavioral testing, staining, network pharmacology, TEM, ELISA, qPCR, and Western blotting.
• Network pharmacology analysis identified 17 putative active compounds and 100 overlapping targets.
• Experimental design includes a control intervention using the TLR4 agonist LPS to test mechanism.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is relatively small at 20.9 MB, which may limit the scope of contained data.

Provenance

Source

figshare

Collection Method

Integrated approach combining network pharmacology and experimental validation using rat models.

Freshness

Last updated 2026-04-29 05:37:31; freshness should be verified.