Data Sheet 2_Isoviolanthin suppresses IL-1β-induced inflammatory and catabolic responses i

Data supporting a 2026 study on the anti-inflammatory effects of isoviolanthin in chondrocytes. The dataset likely contains results from network pharmacology, molecular docking, and in vitro assays, including Western blot, RT-qPCR, and immunofluorescence measurements. It was authored by Jian-Li Yin and published on figshare under a CC-BY-4.0 license.

Use Cases

• Validate network pharmacology predictions based on the 141 overlapping targets identified.
• Analyze the effects of isoviolanthin on inflammatory mediator expression based on CXCL3, CXCL6, IL-6, iNOS, TNF-α, IL-1β, and COX2 measurements.
• Study extracellular matrix metabolism changes based on collagen II, ACAN, and SOX9 anabolism data.
• Investigate signaling pathway inhibition based on PI3K-AKT and MAPK phosphorylation data.
• Correlate RXFP1 expression modulation with anti-inflammatory effects based on mRNA and protein level data.

Strengths

• The dataset is associated with a detailed methodological description including network pharmacology, molecular docking, and multiple in vitro assays.
• Specific experimental conditions are documented, such as the use of 25 μM isoviolanthin concentration and IL-1β stimulation.
• The data is published under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 14.0 KB, indicating a very limited scope, likely containing summary or key result tables rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Likely contains processed results from network pharmacology analysis, molecular docking simulations, and laboratory assays on primary rat chondrocytes.

Freshness

Last updated 2026-05-22 11:16:23; freshness should be verified.