Data Sheet 2_Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell se

A 1.0 MB document from figshare, authored by Jinfeng Li and last updated on 2026-05-26, describes experimental data from a study investigating links between periodontitis and systemic disease. The research used BALB/c mice aged 5–42 weeks, inducing periodontitis via ligation and analyzing splenic CD4+ T cells through flow cytometry, RNA-seq, and adoptive transfer into arthritis models. Findings suggest periodontal inflammation may prime T cells for senescence and exacerbate collagen antibody-induced arthritis.

Use Cases

• Investigating the molecular mechanisms of T-cell senescence based on RNA-seq analysis of differentially expressed genes.
• Modeling the systemic impact of oral inflammation based on adoptive transfer experiments into nude mice with induced arthritis.
• Analyzing senescence-associated secretory phenotype (SASP) cytokine profiles from in vitro stimulated T cells.
• Studying the correlation between periodontal disease and autoimmune exacerbation using a ligature-induced mouse model.

Strengths

• Data is associated with a specific, peer-reviewed experimental methodology using mouse models and multiple assays (flow cytometry, RNA-seq).
• The study includes a temporal analysis, with senescence markers peaking at 18 weeks post-induction.
• Dataset is openly shared under a CC-BY-4.0 license, permitting reuse with attribution.

Limitations

• The primary data file is a DOCX document (1.0 MB); underlying raw numerical or sequence data may not be directly accessible.
• Row and column counts for any underlying datasets are unknown, limiting assessment of scale and structure.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental data from a laboratory study using BALB/c mice, with periodontitis induced by silk ligation and subsequent cellular and molecular analysis.

Time Range

Study involved mice aged 5–42 weeks.

Freshness

Last updated 2026-05-26 06:03:40; freshness should be verified.