Lung scRNA-seq Data from Mice with Osteogenesis Imperfecta

Single-cell RNA sequencing data from the lungs of Col1a1 Aga2/+ mice, a model for osteogenesis imperfecta, reveals chronic inflammation and an emphysematous phenotype. The dataset, 5.7 MB in size, was authored by Jennifer Zieba and last updated on March 17, 2026. It is shared under a CC-BY-4.0 license on the figshare platform.

Use Cases

• Analyze cell type transitions, such as AT2 to AT1 cell differentiation, based on the single-cell transcriptomic profiles.
• Investigate fibroblast activation and differentiation pathways in a diseased lung environment.
• Study chronic inflammation signatures, including NLRP3 inflammasome expression and IL1B/TNF pathway activation.
• Examine the role of decreased Scgb1a1 expression across immune, epithelial, and fibroblast cells in lung disease models.

Strengths

• Data is derived from a specific and well-described mouse model (Col1a1 Aga2/+) for a human disease.
• Analysis reveals specific molecular mechanisms like increased neutrophil/monocyte numbers and NLRP3 inflammasome expression.
• Shared under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is relatively small at 5.7 MB, potentially limiting the scope of secondary analyses.

Provenance

Source

figshare

Collection Method

Single-cell RNA sequencing of lung tissue from a genetically modified mouse model.

Time Range

Data likely corresponds to the experimental period described, but specific dates are not provided.

Freshness

Last updated 2026-03-17 13:07:49.

Geography

Laboratory research, likely from a specific institution; geographic coverage is not specified.